Uncovering the Truth After 18 Years: A Case of Generalized Lipodystrophy Misdiagnosed as Type 1 Diabetes in a Saudi Female from Al-Baha, Saudi Arabia

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Published: Dec 25, 2025
DOI: https://doi.org/10.64753/jcasc.v10i4.3668
Keywords:
lipodystrophy, AGPAT2, CGLs.

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Mohammed Abdullah Alzahrani
Consultant of Diabetology and Family Medicine
Alzandi, Hassan U
GS , Upper GIT , Thoracic surgery Consultant
Ali Dakhel Alghamdi
Consultant Family Medicine.
Saud Mohammed Hassan Alzahrani
Nursing Specialist.
Alghamdi, Raad J
Family Medicine.
Alzahrani, Saeed A
Family Medicine.
Alghamdi, Omair M
Pediatric Endocrinologist
Abuobaida E. E. Abukhelaif
Department of Pathology Faculty of Medicine, Al-Baha University, Saudi Arabia

Abstract

Congenital generalized lipodystrophy type 1 (CGL1) is a very rare autosomal recessive genetic mutation with generalized lipoatrophy and metabolic complications. We report CGL1 in A Saudi female in albaha with lipoatrophy, diabetes mellitus, hypertriglyceridemia, steatohepatitis, and acanthosis due to very rare homozygous 1‐acylglycerol‐3‐phosphate O‐acyltransferase β (AGPAT2) genetic variant.

Article Details

How to Cite
Alzahrani, M. A., U, A. H., Alghamdi, A. D., Alzahrani, S. M. H., J, A. R., A, A. S., … Abukhelaif, A. E. E. (2025). Uncovering the Truth After 18 Years: A Case of Generalized Lipodystrophy Misdiagnosed as Type 1 Diabetes in a Saudi Female from Al-Baha, Saudi Arabia. Journal of Cultural Analysis and Social Change, 10(4), 3856–3859. https://doi.org/10.64753/jcasc.v10i4.3668
Issue
2025: Volume 10 Issue 4
Section
Articles